Which of the following is true in the pathogenesis of chronic pancreatitis?
A. There is accumulation of damaging lipid granules in pancreatic stellate cells.
B. Chronic alcohol use decreases protein content of pancreatic secretions.
C. There is disorientation of acinar cell secretory function.
D. There is migration of ductal cells into the acini.
Ans-C
Among the hypothesized pathophysiologic mechanisms in chronic pancreatitis, the secretion of pancreatic enzyme precursors is altered such that the enzymes are secreted at the basolateral membrane
of the acinar cells rather than at the apical location. This secretion in turn causes local damage and
acinar cell necrosis. Pancreatic secretions in chronic pancreatitis are protein rich and lack adequate
bicarbonate, causing increased viscosity and obstruction of the ducts. Stellate cells become activated,
lose their lipid granules, and propagate a fibrotic response. Pancreatic ductal cells may also
be damaged and exhibit degrees of metaplasia and fibrosis.
A. There is accumulation of damaging lipid granules in pancreatic stellate cells.
B. Chronic alcohol use decreases protein content of pancreatic secretions.
C. There is disorientation of acinar cell secretory function.
D. There is migration of ductal cells into the acini.
Ans-C
Among the hypothesized pathophysiologic mechanisms in chronic pancreatitis, the secretion of pancreatic enzyme precursors is altered such that the enzymes are secreted at the basolateral membrane
of the acinar cells rather than at the apical location. This secretion in turn causes local damage and
acinar cell necrosis. Pancreatic secretions in chronic pancreatitis are protein rich and lack adequate
bicarbonate, causing increased viscosity and obstruction of the ducts. Stellate cells become activated,
lose their lipid granules, and propagate a fibrotic response. Pancreatic ductal cells may also
be damaged and exhibit degrees of metaplasia and fibrosis.
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