Which of the following statements regarding Hürthle cell carcinoma
is false?
A. It represents a subtype of follicular thyroid cancer.
B. Hürthle cell carcinoma accounts for 3% of all thyroid
malignancies.
C. It is more likely than follicular cancer to be multifocal.
D. It demonstrates poor radioactive iodine uptake.
E. Lymph node dissection is indicated for all patients.
COMMENTS: Hürthle cell carcinoma is considered a subtype
of follicular carcinoma and, similarly, is characterized by vascular
or capsular invasion. Of all thyroid malignancies, Hürthle cell
cancers account for about 3%. Different from follicular carcinoma,
Hürthle cell cancers are more often multifocal and bilateral, have
a higher rate of local nodal metastases, and demonstrate poor
radioactive iodine uptake. In part because of these features, Hürthle
cell carcinomas have also been associated with higher mortality
than follicular cancers. Previous radiation exposure has been correlated
with an increase in bilateralism and multicentricity of
Hürthle cell neoplasms, as well as an increased incidence of contralateral
non–Hürthle cell malignant thyroid lesions. The 10-year
survival rate of patients with Hürthle cell carcinoma is 70%.
Approximately 10% to 20% of patients have lymph node metastasis
when initially seen.
A N S W E R : E
is false?
A. It represents a subtype of follicular thyroid cancer.
B. Hürthle cell carcinoma accounts for 3% of all thyroid
malignancies.
C. It is more likely than follicular cancer to be multifocal.
D. It demonstrates poor radioactive iodine uptake.
E. Lymph node dissection is indicated for all patients.
COMMENTS: Hürthle cell carcinoma is considered a subtype
of follicular carcinoma and, similarly, is characterized by vascular
or capsular invasion. Of all thyroid malignancies, Hürthle cell
cancers account for about 3%. Different from follicular carcinoma,
Hürthle cell cancers are more often multifocal and bilateral, have
a higher rate of local nodal metastases, and demonstrate poor
radioactive iodine uptake. In part because of these features, Hürthle
cell carcinomas have also been associated with higher mortality
than follicular cancers. Previous radiation exposure has been correlated
with an increase in bilateralism and multicentricity of
Hürthle cell neoplasms, as well as an increased incidence of contralateral
non–Hürthle cell malignant thyroid lesions. The 10-year
survival rate of patients with Hürthle cell carcinoma is 70%.
Approximately 10% to 20% of patients have lymph node metastasis
when initially seen.
A N S W E R : E
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