The reticuloendothelial function of the liver is primarily dependent on which of the following cells?
A. Hepatocytes
B. Kupffer cells
C. Histiocytes
D. Ito cells
E. All of the above
COMMENTS: The reticuloendothelial system (RES) functions
to clear the circulation of particulate matter and microbes. The RES
consists of fixed phagocytic cells located primarily in the liver,
spleen, and lungs. Kupffer cells are responsible for the reticuloendothelial
function of the liver. Located along the lining of the
hepatic sinusoids (along with the sinusoidal endothelial cells), they
are uniquely positioned to phagocytize and process gut antigens
from the splanchnic and systemic circulation. Kupffer cells play an
important role in the production and control of various cytokines
and inflammatory regulators. Histiocytes are macrophages in connective
tissue. Ito cells, also call hepatic stellate cells, are perisinusoidal
cells involved in collagen and vitamin A metabolism.
A N S W E R : B
A. Hepatocytes
B. Kupffer cells
C. Histiocytes
D. Ito cells
E. All of the above
COMMENTS: The reticuloendothelial system (RES) functions
to clear the circulation of particulate matter and microbes. The RES
consists of fixed phagocytic cells located primarily in the liver,
spleen, and lungs. Kupffer cells are responsible for the reticuloendothelial
function of the liver. Located along the lining of the
hepatic sinusoids (along with the sinusoidal endothelial cells), they
are uniquely positioned to phagocytize and process gut antigens
from the splanchnic and systemic circulation. Kupffer cells play an
important role in the production and control of various cytokines
and inflammatory regulators. Histiocytes are macrophages in connective
tissue. Ito cells, also call hepatic stellate cells, are perisinusoidal
cells involved in collagen and vitamin A metabolism.
A N S W E R : B
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