A newborn male has hypocalcemia and cardiac abnormalities. Which of the following immunologic disorders should be considered?
- DiGeorge syndrome
- Wiskott-Aldrich syndrome
- Severe combined immunodeficiency syndrome
- Adenosine deaminase deficiency
- Chronic granulomatous disease
In DiGeorge syndrome, there is a defect in tissues derived from the third and fourth brachial arches. Hypocalcemia and cardiac abnormalities as well as distinct facial and jaw features are noted in affected individuals. The absence of a thymus has major immunologic consequences.
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