Retinoic acid in high doses is sometimes used for the treatment of skin diseases, including common acne. Retinoic acid can cause many toxic effects at high doses. The most important of these toxic effects is
- Bone demineralization, which leads to pathological fractures
- Connective tissue weakness with multiple small subcutaneous hemorrhages
- Teratogenic effects during the first trimester of pregnancy
- Peripheral neuropathy
- Amnesia
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