Monday, October 13, 2014

NEET 2014 PG Mediclal

A pregnant woman was hospitalized and catheterized with a Foley catheter. She developed a urinary tract infection caused by Pseudomonas aeruginosa and was treated with gentamicin. Which of the following adverse effects was a risk to the fetus when the woman was on gentamicin?
  • Skeletal deformity.
  • Hearing loss.
  • Teratogenesis.
  • Blindness.
  • Mental retardation.

Saturday, October 11, 2014

Writing Hypotheses: a student lesson

Writing Hypotheses: a student lesson

Purpose: to learn when and how to write hypotheses.
Most students believe that they are going to be experimenting anytime they are given a laboratory assignment in science. However, more often than not, students are doing something other than experiments. This is not necessarily bad. A good deal of science is observational and descriptive. For example, the study of bio-diversity usually involves looking at wide variety of specimens and maybe sketching and recording their unique characteristics. However, there are other times when we science teachers are trying to teach students how scientists work and how we can verify things which others may say or believe is so without any proof.
To learn about what is not known or to verify a notion, the so-called "scientific method" might be carried out and an actual experiment may be conducted. It does not matter that your experiment has been done a thousand times before or that your teacher already knows the results. What matters is that you don't know the results and that you can independently find a verifiable answer. In real experiments, real hypotheses should be written before the actual experiment.

What Is a Real Hypothesis?

A hypothesis is a tentative statement that proposes a possible explanation to some phenomenon or event. A useful hypothesis is a testable statement which may include a prediction. A hypotheses should not be confused with a theory. Theories are general explanations based on a large amount of data. For example, the theory of evolution applies to all living things and is based on wide range of observations. However, there are many things about evolution that are not fully understood such as gaps in the fossil record. Many hypotheses have been proposed and tested.

When Are Hypotheses Used?

The key word is testable. That is, you will perform a test of how two variables might be related. This is when you are doing a real experiment. You are testing variables. Usually, a hypothesis is based on some previous observation such as noticing that in November many trees undergo color changes in their leaves and the average daily temperatures are dropping. Are these two events connected? How?
Any laboratory procedure you follow without a hypothesis is really not an experiment. It is just an exercise or demonstration of what is already known.

How Are Hypotheses Written?

  1. Chocolate may cause pimples.
  2. Salt in soil may affect plant growth.
  3. Plant growth may be affected by the color of the light.
  4. Bacterial growth may be affected by temperature.
  5. Ultra violet light may cause skin cancer.
  6. Temperature may cause leaves to change color.
All of these are examples of hypotheses because they use the tentative word "may.". However, their form is not particularly useful. Using the word may does not suggest how you would go about proving it. If these statements had not been written carefully, they may not have even been hypotheses at all. For example, if we say "Trees will change color when it gets cold." we are making a prediction. Or if we write, "Ultraviolet light causes skin cancer." could be a conclusion. One way to prevent making such easy mistakes is to formalize the form of the hypothesis.

Formalized Hypotheses example: If skin cancer is related to ultraviolet light , thenpeople with a high exposure to uv light will have a higher frequency of skin cancer.
If leaf color change is related to temperature , then exposing plants to low temperatures will result in changes in leaf color.
Notice that these statements contain the words , if and then. They are necessary in a formalized hypothesis. But not all if-then statements are hypotheses. For example, "If I play the lottery, then I will get rich." This is a simple prediction. In a formalized hypothesis, a tentative relationship is stated. For example, if the frequency of winning isrelated to frequency of buying lottery tickets. "Then" is followed by a prediction of what will happen if you increase or decrease the frequency of buying lottery tickets. If you always ask yourself that if one thing is related to another, then you should be able to test it.
Formalized hypotheses contain two variables. One is "independent" and the other is "dependent." The independent variable is the one you, the "scientist" control and the dependent variable is the one that you observe and/or measure the results. In the statements above the dependent variable is blue and the independent variable is red.
The ultimate value of a formalized hypothesis is it forces us to think about what results we should look for in an experiment.
Rewrite the first four hypotheses using the formalized style shown above. Single underline the dependent variable and double underline the independent variable in the If clause of each hypothesis. When you are done, write one more original hypothesis of your own using this form. _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________ _________________________________________________________
Anecdotal Information: This is a writing lesson to lay the foundation for using hypotheses in lab activities throughout the course. The lesson is guided practice and my approach to it is "guided lecture." In this technique, I use randomly selected cards with student names on them to answer questions about what they have read up to the section called "Formalized Hypotheses." Questions I ask include the meanings of key vocabulary, give examples, and the meaning of selected passages. In this way I check their understanding as well as develop the foundation for the why and the how of writing formalized hypotheses. Students then examine and discuss the models, after which I prompt them to rewrite the first four hypotheses using the model as a guide.
I cruise the classroom and check every student for progress and provide guidance and clarification for those who struggle. The final product is an original student hypothesis of their choosing. About two-thirds of the students get it the first time. The others struggle with it sometimes well into the first several labs in which hypotheses are featured. The most common problem is that students write a simple statement that is a cause and effect relationship that makes a prediction (example: "If I eat chocolate, then I will get pimples."). They have to be reminded that what makes a hypothetical statement is the idea that two things might be, but not necessarily related. In other words they failed to state a proposed relationship before making the prediction. Literally speaking, cause and effect statements are based on unstated assumptions. In models for scientific research, minimizing assumptions first and then stating your hypothesis is how variables are controlled. A lot of difficulties in writing hypotheses can be traced back to the simple lack of writing skill. I don't let this deter me because students need to learn how to write in all subjects. Hypothesis writing is just one more contribution to overall literacy.
Ref-http://www.accessexcellence.org/LC/TL/filson/writhypo.php

NEET 2014 Medical PG MCQ SPM

Adjuvant used in DPT is
(a) Silica
(b) Magnesium
(c) Manganese
(d) Aluminium
Ans- D
What are some examples of adjuvants?
Aluminum gels or aluminum salts are the only vaccine adjuvants currently licensed for use
Small amounts of aluminum are added as an adjuvant to help stimulate better responses to vaccines. Aluminum is one of the most common metals found in nature and is present in air, food, and water.
How long have adjuvants been used in vaccines?
Aluminum salts, such as aluminum hydroxide, aluminum phosphate, and aluminum potassium sulfate have been used in vaccines for more than 70 years. Aluminum salts were used in the 1930s, 1940s, and 1950s with diphtheria and tetanus vaccines and were found initially to enhance immune responses to protect against tetanus and diphtheria after immunization.
The adjuvant aluminum is present in childhood vaccines that prevent hepatitis A, hepatitis B, diphtheria-tetanus-pertussis (DTaP, Tdap) Haemophilus influenzae type b (Hib), human papillomavirus (HPV) and pneumococcus infection. This adjuvant has been used safely in vaccines for decades.

Thursday, October 9, 2014

NEET PG Medical 2014

Calcium is required for the activation of
the enzyme
a.Isocitrate dehydrogenase
b.Fumarase
c.Succinate thiokinase
d.ATPase
Ans -
D
Expl-
The effect of Ca2+ and calmodulin on (CaM) on the activation of Ca2+-dependent Mg2+-activated ATPase (Ca2+,Mg2+-ATPase; ATP phosphohydrolase, EC 3.6.1.3) has been carried out because of the finding that the CaM dependence of the activation varies with the concentration of free Ca2+, similarly to brain phosphodiesterase and adenylate cyclase. The study was carried out in the absence of chelating agents because they strongly interfere in the enzyme kinetics. Three main conclusions can be drawn (i) CaM-Ca3 and CaM-Ca4 together are the biochemically active species in vitro. (ii) These species bind in a non-cooperative way to the CaM-binding site of the enzyme with a dissociation constant of 6 x 10(-10) M or 1.1 x 10(-8) M, depending on whether Ca2+ saturates the substrate binding site of the enzyme or not. (iii) The binding of CaM-Ca3 to the enzyme lowers the dissociation constant of the enzyme for Ca2+ at the substrate binding site from 51.5 to 2.8 microM. Contrary to general belief, CaM does not induce pronounced positive cooperativity in the binding of Ca2+ to the enzyme. Such a cooperativity is seen only when the enzyme is incompletely saturated with the activator, but it disappears in the presence of saturating concentrations of CaM-Ca3. The rate equation proposed here accurately predicts the extent of enzyme activation over a wide range of Ca2+ and CaM concentration. In healthy erythrocytes the concentrations of Ca2+ and CaM are such that the Ca pump works with a minimal dissipation of energy, but a small increase in the intracellular Ca2+ concentration leads to a strong amplification of the pumping activity

Wednesday, October 8, 2014

NEET 2014 PG Medical

Human feet are everted so that their soles lie fully on the
ground during ambulation. What muscle is developmentally
unique to humans, inserts into the base of the fi fth metatarsal,
and assists in eversion (or pronation)?
(A) Extensor digitorum longus
(B) Extensor digitorum brevis
(C) Fibularis longus
(D) Fibularis tertius
(E) Flexor digiti minimi brevis
The answer is D: Fibularis tertius. The fibularis (peroneus)
tertius muscle arises off the distal portion of the extensor
digitorum longus muscle and attaches to the dorsal surface
of the base of the fifth metatarsal. This muscle is rarely
found in other primates and is functionally linked to effi cient
terrestrial bipedalism. Though this muscle may be highly variable
in human specimens, it is important in eversion of the
foot during ambulation and may have a proprioceptive role
to guard against excessive inversion of the foot at the ankle
joint. Choice A (Extensor digitorum longus) is incorrect.
The extensor digitorum longus arises off the superiolateral
aspect of the tibia and interosseous membrane and inserts
into the middle and distal phalanges of the lateral four digits.
This muscle extends the lateral four digits and dorsiflexes
the ankle. It does not insert into the base of the fifth metatarsal
or assist in eversion. It does give rise to the fi bularis
tertius muscle distally. Choice B (Extensor digitorum brevis)
is incorrect. The extensor digitorum brevis is an intrinsic foot
muscle that inserts into the middle phalanges of the lateral
four digits to extend these toes. It does not insert into the
base of the fi fth metatarsal or assist in eversion. Choice C
(Fibularis longus) is incorrect. The fi bularis longus muscle
arises off the proximal aspect of the fi bula and inserts into
the base of the fi rst metatarsal and medial cuneiform bone.
This muscle is important in eversion of the foot; however,
it can be eliminated due to its medial insertion in the foot.
Choice E (Flexor digiti minimi brevis) is incorrect. The fl exor
digiti minimi brevis arises from the base of the fi fth metatarsal
and inserts into the base of the proximal phalanx of the fi fth
digit. It does not participate in eversion of the foot, so this
answer can be easily eliminated.

Tuesday, October 7, 2014

NEET PG Medical 2014 Anesthesia MCQs

A 1-month-old infant with a strong family history of sickle-cell anemia is brought to the emergency room with an
incarcerated inguinal hernia. Which of the following should be carried out before surgery?
A. Sickle cell prep
B. Hemoglobin electrophoresis
C. Peripheral smear
D. Hematology consultation
E. None of the above
Answer
(E) At birth, the concentration of hemoglobin F (fetal hemoglobin) is about 80% and reaches its lowest level by 2 to 3 months of age. Sickle-cell anemia (hemoglobin SS) is an inherited disorder of the β-chain of the adult hemoglobin molecule caused by a single amino acid substitution. It has an incidence of about 0.2% in the African-American population, in contrast to the relatively benign heterozygous condition, sickle cell trait (hemoglobin AS), which affects 8% to 10% of the same group. Sickling can occur in homozygous patients who become hypoxic, acidotic, hypothermic, or dehydrated. The predominant hemoglobin in this 1-month-old infant is hemoglobin F, which would temporarily protect the infant from the manifestations of sickle-cell anemia were he or she homozygous for hemoglobin S. The patient should, however, be worked up for sickle-cell anemia at
some point in early life, but such a workup is not a prerequisite for surgery at 1 month of age (Miller: Anesthesia,ed 6, pp 1112-1113; Motoyama: Smith’s Anesthesia for Infants and Children, ed 7, pp 49, 397-398; Stoelting: Anesthesia and Co-Existing Disease, ed 5, pp 411-412).

Thursday, October 2, 2014

NEET PG Medical MCQ 2014

For the description below, choose the SINGLE most appropriate drug treatment.
A 27-year-old woman presents at 33 weeks in her first pregnancy. She is complaining of generalized itching, worse on the palms of her hands and soles of her feet.Abdominal examination is unremarkable. Blood investigations reveal that she has increased bile acids.
a.Calcium supplements
b.Erythromycin
c.Nifedipine
d.Magnesium sulphate
e.Ursodeoxycholic acid

Answer
E
Ursodeoxycholic acid is used in the symptomatic treatment of obstetric cholestasis. It chelates bile acids and reduces the itching associated with the disorder. Ursodeoxycholic acid (INN, BAN and AAN), also known as ursodiol (USAN) and the abbreviation UDCA, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria.A Cochrane review looking at primary biliary cirrhosis found that although ursodeoxycholic acid showed a reduction in liver biochemistry, jaundice, and ascites, it did not decrease mortality or liver transplantation
Ursodiol is the only FDA approved drug to treat primary biliary cirrhosis.
The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery. The drug is very expensive, however, and if the patient stops taking it, the gallstones tend to recur if the condition that gave rise to their formation does not change. For these reasons, it has not supplanted surgical treatment by cholecystectomy.